Mutation Induction in Humans and Mice: Where Are We Now?

Dubrova Dubrova

doi:10.3390/cancers11111708

Abstract

The analysis of mutation induction in human families exposed to mutagens provides the only source of reliable estimates of factors contributing to the genetic risk of human exposure to mutagens. In this paper, I briefly summarize the results of recent studies on the pattern of mutation induction in the human and mouse germline. The results of recent studies on the genome-wide effects of exposure to mutagens on mutation induction in the mammalian germline are presented and discussed. Lastly, this review also addresses the issue of transgenerational effects of parental exposure to mutagens on mutation rates in their non-exposed offspring, which are known as transgenerational instability. The possible contribution of transgenerational instability to the genetic risk of human exposure to mutagens is discussed.

Highlights

Given that mutations induced in the germline can persist for a number of generations following parental exposure to mutagens, they may substantially contribute to the burden of inherited diseases and represent one of the key risk factors of human exposure to mutagens [1,2,3]
The aim of this Review is, to present and discuss the progress made in the field of mutation induction in the mammalian germline and to examine its potential contribution to our current understanding of the factors contributing to the genetic risk of human exposure to mutagens
We detected a significant increase in the mini satellite mutation rate (Figure satellite mutation mutationrate ratewas was analyzed in germline the germline of irradiated rate (Figure1)

Summary

Introduction

Given that mutations induced in the germline can persist for a number of generations following parental exposure to mutagens, they may substantially contribute to the burden of inherited diseases and represent one of the key risk factors of human exposure to mutagens [1,2,3]. It should be stressed that to date some fundamental gaps remain in our understanding of the pattern of mutation induction in humans. The aim of this Review is, to present and discuss the progress made in the field of mutation induction in the mammalian germline and to examine its potential contribution to our current understanding of the factors contributing to the genetic risk of human exposure to mutagens

Mutation Induction in the Human and Mouse Germline

Transgenerational Effects of Parental Exposure to Mutagens

Findings

Conclusions