Abstract
Spontaneous mutation in man was reviewed in this series almost a decade ago (Vogel and Rathenberg, 1975). These authors remarked that mutation rates in general, and human rates in particular, had not been the subject of the extensive, systematic study that might be expected from the importance of the subject. That statement is still true. As mentioned by Vogel and Rathenberg, estimates of human mutation rates depend on large epidemiologic studies of a type that were more popular in the 1940s and 1950s than since. As a result, the values given in still earlier reviews (Penrose, 1961; Crow, 1961) do not differ importantly from those of more recent reviews, including the present one.
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