Abstract
The structure of hydrogel nanoparticles (CHP nanogels), formed by self-aggregation of cholesterol-bearing pullulan (CHP) was studied by dynamic light scattering (DLS) and small-angle neutron scattering (SANS). The interactions between the CHP nanogel and methyl-β-cyclodextrin (CD) or protein (hen egg white) were also investigated. It was revealed by SANS that the nanogels were spherical in shape with a radius of 6.7 nm. The following two functions were disclosed. (1) CHP nanogels were dissociated by the addition of CD and formed inclusion complexes with cholesteryl groups, leading to suppression of hydrophobic interaction between the cholesteryl groups. (2) The nanogel behaved as a molecular chaperone (heat shock protein-like activity) when CHP nanogel was mixed with hen egg white and heated up to 75 °C. The egg white aqueous solutions with CHP nanogel remained transparent while the egg white without CHP nanogel became opaque.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
