Abstract
The most significant risk factor for cancer is age. 1 Cohen HJ Biology of aging as related to cancer. Cancer. 1994; 74: 2092-2100 Crossref PubMed Scopus (75) Google Scholar One potential contributing cause may be an age-related accumulation of somatic cell mutations. If this putative accumulation is due to an increase in a specific mutational event, it should be possible to detect an altered mutational spectrum in cancers removed from older patients. We have searched for such a mutational signature in primary ovarian tumours of epithelial origin obtained from 113 patients treated at the University of Kentucky from 1990 to 1994. The mean and median age at diagnosis of these patients was 55·3 and 56 years, respectively. Our study focused on loss of heterozygosity on chromosome 17 because this type of genetic alteration is common in ovarian cancer. 2 Pieretti M Cavalieri C Conway PS Gallion HH Powell DE Turker MS Genetic alterations distinguish different types of ovarian tumors. Int J Cancer. 1995; 64: 434-440 Crossref PubMed Scopus (68) Google Scholar
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