Abstract
18537 Background: *Chromosomal aberrations are important events in the pathogenesis of lymphoma & leukaemias P53 belongs to class of genes whose functions involves negative regulation of cell growth through certain protein synthesis which leads to arrest of the cell cycle at growth phase. *Elucidate the nature of P53 in cases with Non Hodjkins lymphoma presented in our province (North east Mediterranean) and the impact of its mutation on known prognostic factors as well as on survival of patients receiving treatment by different chemotherapy protocols. Methods: Study done on 34 patients and 10 normal contorls Conclusions: *P53 +ve mutations in patients with lymphoma outnumbered those with −ve mutations. *Positivity degree is increased in higher grade than lower grade lymphoma. *Dfs is prolonged in those with −ve mutations than in subgroups with +ve mutations. *Subgroups with negative Exon mutations carry better survival than those with +ve mutations. [Table: see text] [Table: see text] [Table: see text] [Table: see text] [Table: see text] [Table: see text] No significant financial relationships to disclose.
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