Abstract
Human fibroblast interferon (HuIFN-β) was studied for mutagenicity using the Ames method and in vitro cytogenetics. HuIFN-β had no mutagenic effect on S. typhimurium (TA1535, TA1537, TA1538, TA98 and TA100) and E. coli (WP2 uvrA) at concentrations of 3, 30, 300, 3000, 30 000 or 300 000 IU/plate. In the cytogenetic study, HuIFN-β had no clastogenic effect on human peripheral blood lymphocytes at concentrations of 3, 30, 300, 3000 or 30 000 IU/ml. These results suggest that HuIFN-β has no mutagenic potential.
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