Mutagenicity of furylfuramide in somatic and germ cells of Drosophila melanogaster.

Abstract

When male larvae carrying unstable white-zeste system were fed on a medium containing 50 and 100ppm AF-2, the incidence of somatic eye-color mutations increased approximately linearly. Since the spontaneous mutation frequency is 0.1%, the doubling dose of AF-2 is estimated at 16ppm. However, when AF-2 dose of 300ppm was given orally to adult females, the incidence of recessive visible mutations at dumpy locus and dominant visible mutations at Minute loci in primary oocytes did not increase above the control level. This indicates that the somatic mutation assay is more sensitive than the germ-cell-mutation assay, at least, after treatment with AF-2 under the conditions used.