Abstract
1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) were tested ∗∗ ∗∗ Human lymphoblast gene-locus mutation assays are covered by U.S. Patents number 4 066 510 and 4 302 535. Patent on the AHH-1 cell line has been applied for. Rights under these patents have been assigned exclusively to Gentest Ltd. Partnership. for the ability to induce gene mutations in two human lymphoblastoid cell lines, designated AHH-1 and TK6. Both chemicals were ‘direct-acting’ mutagens in both cell lines. DBE was essentially equally mutagenic in TK6 cells and AHH-1 cells. In contrast, DCE was 25-fold more mutagenic in the AHH-1 cell line than in the TK6 cell line. This differential sensitivity between AHH-1 cells and TK6 cells was related to the levels of glutathione S-transferase activity in these two cell lines.
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