Abstract
The 8-aminoquinolines, primaquine, pentaquine and pamaquine, were investigated for mutagenic activity in Salmonella typhimurium strains TA100, TA98, TA97 and TA102 in the rat liver microsomal activation system. Primaquine and pentaquine induced mutations in TA97 in the presence and absence of S9 mix. Pamaquine was mutagenic to TA98 only in the absence of S9 mix.
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