Abstract
Treatment of Drosophila males with 1–20% vinyl chloride in air gave an increased frequency of complete and mosaic recessive lethals. Pretreatment with phenobarbiturate for 24 h caused an increase in the mutagenic effect of vinyl chloride. This indicates that the mixed-function oxygenase system can be induced in Drosophila in the same way as in mammals.
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Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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