Abstract
A sister chromatid exchange (SCE) analysis was performed on circulating lymphocytes collected from young human volunteers exposed to 0.5 ppm ozone for 2 hr, an exposure simulating conditions in severe air pollution episodes. SCE analysis was also performed on diploid human fetal lung cells (WI-38) exposed to 0, 0.25, 0.50, 0.75, and 1.00 ppm ozone for 1 hr in vitro. No increase in SCEs over controls was demonstrated in the lymphocyte chromosomes. However, a clear dose-related increase in SCEs was observed in the WI-38 cells exposed in vitro.
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