Abstract
Methyl alkylamino methanesulfonates are mutagenic agents as shown by treating several strains of E. coli at pH 7. Methyl methylaminosulfonate (CH 3NH-SO 3CH 3) was more efficient than methyl ethylaminosulfonate (C 2H 5NHSO 3CH 3) which itself was more efficient than methyl isopropylaminosulfonate (C 3H 7NHSO 3CH 3). Methyl methylaminosulfonate seemed to be at least as effective as methyl methanesulfonate (CH 3SO 3CH 3). Methyl methylaminosulfonate produced a yield of up to 1% of auxotrophic mutants. All three new mutagens appeared to react according to the same mechanism by ester fission and methylation of nucleophilic groups as is known for methyl methanesulfonate. The reaction mechanism seems to be of the S N2 type.
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