Abstract
Human androgen receptor gene mutations in patients uit clinically localized prostate cancerThe aim of this study was to detect mutations in the human androgen receptor gene in radical prostatectomy specimens. Material and methodsThe genomic sequence was realized in 67 radical prostatectomy specimens. The mean age was 64 years old. The PSA median was 15 ng/ml. TNM 1997: 34.3% were T1 and 65.7% T2.Genomic sequence: 1. Radical prostatectomy specimens desparaffitation. 2. Extraction of the DNA 3. DNA amplification. 4. Automatic genome sequence. 5. Comparison with Gene-Bank. Results16.7% of the specimens were mutated. The most frequent mutation was the puntual mutation. The exon most frecuent mutated was exon 1.
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