Abstract
We report a novel self-rolling, conductive, and biocompatible multiwall carbon nanotube (MWCNT)-dopamine-polyethylene glycol (PEG) hydrogel film. The gel can self-fold into a thin tube when it is transferred from a glass slide to an aqueous environment, regardless of the concentrations of the MWCNT. The film presents a highly organized pattern, which results from the self-assembly of hydrophilic dopamine and hydrophobic carbon nanotubes. By exploring the biomedical potential, we found that MWCNT-included rolled film is nontoxic and can promote cell growth. For further functional verification by qPCR (quantitative polymerase chain reaction), bone marrow derived mesenchymal cells present higher levels of osteogenic differentiations in response to a higher concentration of CNTs. The results suggest that the self-rolling, conductive CNT-dopamine-PEG hydrogel could have multiple potentials, including biomedical usage and as a conductive biosensor.
Highlights
A most efficient and popular method for tissue regeneration involves a three dimensional (3D) matrix that provides a stable and tissue-mimicking environment for cell proliferation and differentiation [1,2,3,4,5]
Poly(ethylene glycol) diacrylate (PEGDA, Mw = 700), F-127, dopamine, and N0 N0 -methylene-bisacrylamide (MBA) were all ordered from Sigma-Aldrich (Oakville, ON, Canada)
The results suggest that multiwall carbon nanotube (MWCNT) barely have any influence on the biocompatibility or microscope, was clearlyThe observed thatsuggest cells were spread all overbarely the curves, or withoutit MWCNT
Summary
A most efficient and popular method for tissue regeneration involves a three dimensional (3D) matrix that provides a stable and tissue-mimicking environment for cell proliferation and differentiation [1,2,3,4,5]. An ideal matrix or cell living environment is generally expected to have an appropriate morphology, mechanical properties, and biological compatibility. It has been a challenge to fabricate an artificial 3D matrix that meets all these requirements. Both natural and synthetic materials have been used to construct 3D matrixes for tissue engineering. Natural materials are generally known to have poor mechanical properties, while synthetic materials often lack cell recognizable receptors. A combination of these two types of materials may be a promising solution for tissue regeneration
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