Abstract
The inflammatory bowel diseases, Crohn's disease and ulcerative colitis, pose a fascinating challenge to specialists in gastroenterology, infectious diseases, immunology and genetics and an often crushing burden to patients and their families.
Highlights
Crohn’s disease was described first in 1904 by a Polish surgeon, Antoni Lesniowski [5], and more thoroughly by Burrill Crohn and his colleagues at the Mount Sinai Hospital of New York in 1932 [6]
When Crohn’s disease (CD) is active, it is usually associated with microcytic anemia, the so-called ‘anemia of inflammation’ induced by excessive hepcidin synthesis in the liver and resultant inactivation of ferriportin
The data supporting that argument were very thin at the time and the discovery of Helicobacter pylori as the cause of peptic ulcer [9] and Tropheryma whipplei as the inciter of Whipple disease [10] drove a very large nail into the coffin of psychosomatic medicine
Summary
Crohn’s disease was described first in 1904 by a Polish surgeon, Antoni Lesniowski [5], and more thoroughly by Burrill Crohn and his colleagues at the Mount Sinai Hospital of New York in 1932 [6]. CD is often associated with various skin rashes (including erythema nodosum), rheumatoid arthritis and uveitis, strongly suggesting an autoimmune basis for the disease to some, but the result of chronic stimulation of cytokine production and T cell activation to others.
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