Abstract
This study was concerned with the effects of prolonged muscular work in healthy subjects on erythrocyte 2,3-diphosphoglycerate as a mediator of acute changes in the affinity of hemoglobin for oxygen. The experimental procedures were designed to elicit marked variation among exercise conditionsin factors which are known or hypothesized to effect oxy-hemoglobin dissociation in vivo, ·... namely respiratory and metabolic acid-base status, temperature, adequacy of systemic O2 transport and length of time to exhaustion. In contrast to a previous report, the only systematic effect of exercise under present conditions was a decline below resting levels in red cell 2,3-DPG which occurred at the mid-point of each work test. Neither the magnitude nor direction of change in 2,3-DPG was related to the physiologic intensity of exercise. Present findings are consistent with the contention that time is a critical determinant of any contribution the generation of erythrocyte 2,3-DPG may make to oxy-hemoglobin affinity, regardless of the apparent intensity of demand for increased O2 delivery.
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