Muscle wasting in the ICU can be reliably monitored using ultrasound

H Jørgensen,B Nedergaard,T Gilsaa

doi:10.1186/cc12377

H Jørgensen, B Nedergaard + Show 1 more

Open Access

https://doi.org/10.1186/cc12377

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Abstract

The aim of this study was to establish the intraobserver and interobserver variation of ultrasonographic measurements of the rectus femoris muscle cross-section area (RF-CSA). Muscle wasting is frequent in the ICU, affecting more than one-half of the patients with severe sepsis [1]. Muscle mass reduces rapidly, and 15 to 20% is lost within the first week [1]. To monitor muscle mass, ultrasound has the benefits of being both readily available in the ICU and non-invasive. Ultrasonographic measurement of RF-CSA has an almost perfect correlation with MRI (mean interclass correlation (ICC) = 0.999) [2] and RF-CSA is linearly related to maximum voluntary contraction strength in both healthy subjects and COPD patients (r = 0.78) [3].

Highlights

Autophagy is well known as one of the biogenic responses against various stresses, which possesses the beneficial roles for survival, but little is known about the dynamics and its significance during the septic condition
community-acquired pneumonia (CAP)-mediated antiinflammatory signals in vagal efferent nerve fibers result in the release of acetylcholine, which interacts with innate immune cells that express the nicotinic acetylcholine receptor subunit α7 (α7nAChR)
The aim of this study was to determine the effects of the α7nAChR-agonist cdp-choline on microcirculatory alterations during experimental endotoxemia

Summary

Introduction

Autophagy is well known as one of the biogenic responses against various stresses, which possesses the beneficial roles for survival, but little is known about the dynamics and its significance during the septic condition. Conclusion The assessment of routine biomarkers (bilirubin, white blood cells and hemoglobin) may be a helpful tool in the decisionmaking process at the bedside, for the evaluation of early ICU admission of recoverable patients, as indicators of inflammatory response, organ dysfunction or catabolism level, and their significant predictive value on mortality. The purpose of this study was to ascertain the prognostic value of proadrenomedullin (pADM), measured in all patients admitted to the ICU of our hospital with a diagnosis of severe sepsis or septic shock during 1 year. The aim of the study is to evaluate life quality after trauma and to identify the most important needs of the patients, in order to improve the level of care after an ICU stay and to implement a faster and more effective reintegration into the active and productive society. We report the results of the baseline phase of this trial

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