Abstract
Muscle Magnetic Resonance Imaging versus Clinical Function in Duchenne Muscular Dystrophy
Highlights
Duchenne muscular dystrophy (DMD) is an X-linked recessive inherited disease, with an incidence of 1 in 3500 newborn males
The gluteus maximus, adductor magnus, and gastrocnemius muscles were the most representative, because they were involved during early stages of DMD and their shapes were easier to distinguish on Magnetic resonance imaging (MRI)
Fatty infiltration grade on muscle MRI corresponded to microscopic parameters, including a reduced number of muscle cells, arrangement disorder, and fatty and connective tissue infiltration
Summary
Duchenne muscular dystrophy (DMD) is an X-linked recessive inherited disease, with an incidence of 1 in 3500 newborn males. DMD is caused by mutations in the dystrophin gene, which is located on the X chromosome (Xp21) and codes for dystrophin, an important skeleton protein of the muscle cell membrane. DMD is characterized pathologically by a progressive loss of muscle fibers and their replacement with fat and connective tissue [1]. DMD is characterized by progressive muscle weakness, which first develops in the proximal pelvic girdle and gradually extends to the distant extremities. Impairment in patients with Duchenne muscular dystrophy (DMD) has been evaluated primarily by muscle fiber microscopy examination. Pathologic examination is limited by the choice of muscle and the invasiveness of muscle biopsy. Magnetic resonance imaging (MRI) of the muscle is a noninvasive method of evaluating muscle preservation
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