Abstract
Experiments were performed in the genetically hypertensive obese rats of Koletsky type (SHR/N-cp) and in their lean siblings of both sexes. Insulin binding to erythrocytes and to adipose tissue, lever tissue and muscle tissue was monitored in the control animals and in the animals under the long lasting terguride treatment. In control animals insulin binding shows substrain and tissue dependence being elevated in lean rats except insulin binding to erythrocytes where inverse is true. Terguride increases percentage of specific insulin binding to erythrocytes in all groups except obese females, terguride increases percentage of specific binding to adipose tissue except lean females, the mentioned drug remained without effect in muscle tissue in all group except lean females where drug induced elevation was detected. The effect of terguride in liver tissue was monitored only in males of both substrains, elevation was found only in lean. GLUT-4 was analyzed only in muscle tissue. The effect of terguride was found in obese females, i.e., in the group which shows reduced GLUT-4 relative to lean females.
Highlights
In our previous study we documented strain dependent insulin binding to erythrocytes (5).It was found profound decrease of insulin binding in the SHR/N-cp obese rats as well as in their lean siblings relative to the normotensive rats of Wistar strain
Terguride increases specific insulin binding to erythrocytes in both substrains of Koletsky rats except obese females (4)
The mentioned data suggest possible causal relationship between glucose intolerance, hyperinsulinemia, and specific insulin binding to erythrocytes
Summary
In our previous study we documented strain dependent insulin binding to erythrocytes (5).It was found profound decrease of insulin binding in the SHR/N-cp obese rats as well as in their lean siblings relative to the normotensive rats of Wistar strain. Terguride increases specific insulin binding to erythrocytes in both substrains of Koletsky rats except obese females (4). Obese females represents the exception, i.e.,in this type of rats terguride induced alleviation of genetically based hyperinsulinemia and glucose intolerance is not accompanied by the changes in specific insulin binding to erythrocytes. It is substantiated looking for a possible drug induced changes in specific insulin binding in the other tissues, i.e., in adipose, muscle and liver tissue. Such experiments verified a possible different drug sensitivity of insulin independent tissue (see erythrocytes) in comparison with drug sensitivity of insulin dependent tissues (see liver, muscle, adipose tissue) (7)
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