Muscle gene expression in heterokaryons.

Abstract

One approach to the study of how gene regulation occurs during muscle differentiation and development is to put a non-muscle cell into an environment where it is reprogrammed to synthesize muscle proteins, which it would never normally express. One way to do this is to fuse two cells together. In this talk I will show you how this kind of fusion system can be used to ascertain the requirements for gene expression and to address certain questions about the determination and differentiation.