Abstract
Abstract Introduction: Crohn’s disease (CD) is an inflammatory bowel disease, marked by exacerbations and remissions periods. Peripheral manifestations in CD may be present with the syndrome of skeletal muscle dysfunction (SMD), which is characterized by loss of muscle strength, fatigue complain, limited exercise capacity and impaired quality of life of these patients. Objective: Evaluate muscle strength, physical capacity and quality of life of patients with CD and compare them with healthy controls. Methods: 18 patients CD and 12 healthy controls matched for age and sex were involved. Peripheral muscle strength evaluated by handgrip strength of the dominant hand and respiratory muscle strength by measures of respiratory muscle strength (maximal inspiratory/expiratory pressure - MIP and MEP). Exercise capacity evaluated by Shuttle test (ST) and the quality of life by the Short-form 36 (SF-36) and by the Inflammatory Bowel Disease Questionnaire (IBDQ). Results: Patients with CD presented a lower respiratory muscle strength (MIP = -68.93 ± 26.61 vs 29.63 ± -100 cmH2O, p = 0.0013 and MEP = 81.07 ± 30.26 vs 108 ± 25.30 cmH2O, p = 0.032) and a tendency the lower peripheral muscle strength (31.72 ± 8.55 vs 39.00 ± 13.37 kgf, p = 0.09). In addition, CD patients presented worse physical capacity on the ST compared to the control group (513.7 ± 237m vs 983.0 ± 263m, p < 0.05) and worse quality of life in 7 of 8 domains of the SF-36 and in all dimensions of the IBDQ. Conclusion: Patients with CD showed muscle functional impairment and poorer quality of life compared to healthy control group. These findings suggest that the assessment and maybe interventions in the muscle function must be used in clinical practice.
Highlights
Crohn's disease (CD) is an inflammatory bowel disease, marked by exacerbations and remissions periods
The final sample consisted of 18 patients with CD and 12 healthy controls
It was allowed to pair a control with the same age and sex for each two patients, which explains the difference in the sample size of each group
Summary
Crohn's disease (CD) is an inflammatory bowel disease, marked by exacerbations and remissions periods. Objective: Evaluate muscle strength, physical capacity and quality of life of patients with CD and compare them with healthy controls. CD patients presented worse physical capacity on the ST compared to the control group (513.7 ± 237m vs 983.0 ± 263m, p < 0.05) and worse quality of life in 7 of 8 domains of the SF-36 and in all dimensions of the IBDQ. Crohn's disease (CD) is an inflammatory bowel disease of unknown origin characterized by the focal involvement, transmural and asymmetric of any part of the digestive tract, from mouth to anus [1]. It is not clinically or surgically curable and its natural history is marked by acute exacerbations and remissions. Besides the manifestations of the digestive system, the CD can show extra intestinal manifestations, the most frequent being ophthalmic (such as uveitis) of the skin (such as erythema nodosum), rheumatic, and often even osteoporosis and arthralgia, as well as malnutrition, fatigue and state of pre cachexia, which increases the potential for complications [4]
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