Abstract
Measurements were made, on microscopic sections, of muscle fiber size and number in 19 cases of African cardiomyopathy. These measurements were made at standard left and right ventricular sites away from the apical areas of scarring. The only significant differences from normal controls were a greater total muscle fiber width in the right ventricle and total wall width. Total heart weight and right ventricular wall thickness as measured in situ at postmortem were also significantly greater. It is inferred that the great increase in weight of the hearts is largely due to elongation of muscle fibers, and that failure of contraction is not due to numerical loss of muscle fibers over the bulk of the ventricle.
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