Abstract
Adenylosuccinate lyase (EC 4.3.2.2; ASase) catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole carboxamide (SAICA) ribotide into aminoimidazole carboxamide (AICA) ribotide along the de novo pathway and the formation of AMP from adenylosuccinate in the conversion of IMP into adenine nucleotides. Both reactions involve the cleavage of a succinyl group, yielding fumarate.1
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