Muscle, endocrine, and immunological markers of frailty in older people.

Abstract

To analyze muscle, endocrine, and immunological markers that influence frailty in older people assisted in primary care. Cross-sectional, analytical, and probabilistic study were linked to the institutional research "Integrated Health Care for Older People." The study population consisted of males and females aged 60years or more and assisted in primary health care. The research protocol included an interview and physical examination to evaluate the frailty criteria. Analysis of the following were done: serum calcium and creatinine as muscle markers; vitamin D, parathyroid hormone, and insulin-like growth factor-1 as endocrine markers; and interleukin-6, C-reactive protein, leukocytes, and neutrophil-lymphocyte ratio as immunological markers. Statistical analysis included the Mann-Whitney test to compare means, and linear regression to analyze the relationship between dependent and independent variables. There was a relationship between creatinine and prediction of weight loss (p<0.001), leukocytes and prediction of handgrip strength (p=0.022), interleukin-6 and prediction of energy expenditure (p=0.026), and vitamin D and prediction of gait time (p=0.036). Also, sex influenced handgrip strength (p<0.001), and age influenced handgrip strength (p<0.001), gait time (p<0.001) and energy expenditure (p<0.001). The joint use of muscle, endocrine, and immunological markers may be useful to diagnose frailty and to propose resolutive interventions to reduce negative outcomes for older people.