Abstract
Pharmacological evidence has indicated the existence of multiple subtypes of muscarinic receptors, while biochemical and immunological data have uncovered the highly conserved nature of muscarinic receptor structure. Molecular biological data now appear to have confirmed the notion of subtypes. Tony Kerlavage, Claire Fraser and Craig Venter discuss recent cloning and sequence analyses of the genes encoding muscarinic receptors in brain and heart which have revealed the existence of four distinct but highly homologous gene products.
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