Abstract
The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.
Highlights
The spleen is a secondary lymphoid organ specialized for filtering blood-borne antigens and removal of old or damaged erythrocytes
It will be imperative to review the splenic location of L-dendritic cells (DC) in relation to other DC and myeloid cell types
CD8aÀ Conventional DC (cDC) are strategically located within the marginal zone where they endocytose antigen in blood carried from the terminating capillaries [3] (Fig. 1)
Summary
The spleen is a secondary lymphoid organ specialized for filtering blood-borne antigens and removal of old or damaged erythrocytes. It comprises two morphologically and functionally distinct compartments (Fig. 1). The white pulp is involved mainly with initiation of immune responses against blood-borne antigens and pathogens It comprises three regions: the T cell zone or periarteriolar sheath (PALS), B cell follicles, and the marginal zone [2]. The marginal zone is strategically situated at the interface of the red pulp and PALS for screening blood-borne antigens and pathogens It contains a large reservoir of resident cells that participate in mounting an adaptive response against blood-borne antigens. The functional importance of all subsets of DC and macrophages/monocytes in spleen is still under investigation in terms of their comparative roles in antigen presentation
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