Abstract
Twenty four per cent of our specific pathogen free BALB/c female control mice and 9% of control males developed lymphoid moplasias Three fourth of the neoplasms were reticulosarcomas type B (Hodgkin's like lesions) Without change in the proportion of reticulosarcomas the tumor incidence was tripled by infecting newborn BALB/c mice with 0.05 ml 5 times concentrated subcellular extracts of reticulosarcomas, doubled by injecting 10 5 XC units of either of two leukemia type viruses recently isolated from BAIB/c mice, and tripled by grafting 10 4 cells from leukemia virus infected syngeneic secondary embryonic fibroblast cultures. Intrathymic inoculation gave the same result as subcutaneous administration 4 four log reduction tn virus given dose s.c. only lowered the tumor incidence slightly. The mean latent period was 13 months following inoculation of cell free virus preparations and 8 month after injection of infected tissue culture fibroblasts. Adult mice receiving onus did not show enhanced tumor incidence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
