Murine pulmonary imaging at 7T: T2* and T1 with anisotropic UTE.

Abstract

To measure the T2* and T1 of mouse lung at 7T via anisotropic-resolution radial ultrashort echo-time imaging with ellipsoidal k-space coverage. Ellipsoidal field-of-view was created by expanding uniform spherical k-space coverage. The effects of T2* and ellipsoidal sampling on image resolution were investigated by using point-spread-function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T2* and T1 of healthy C57BL/6 mice at the increasingly common preclinical field strength of 7T. Lung parenchyma T2* of 17- to 23-week-old mice at 7T was 0.395 ± 0.033 ms. T1 of lung and left- and right-heart ventricles was 1452.5 ± 87.0 ms, 1810.5 ± 54.6 ms, and 1602.6 ± 120.9 ms, respectively. Ellipsoidal k-space sampling provides enhanced resolution for a fixed scanning time or provides equivalent (although anisotropic) spatial resolution with reduced scanning times, while simultaneously avoiding fold-in artifacts. Using these techniques, the first T2* and T1 measures of mouse lung at 7T are reported. Ultrashort echo-time imaging with ellipsoidal k-space coverage significantly increases in-plane resolution without increasing scanning time, or equivalently, decreases scanning time while maintaining equivalent in-plane resolution. Magn Reson Med 79:2254-2264, 2018. © 2017 International Society for Magnetic Resonance in Medicine.