Abstract
Objective: The study investigates the effect of a localized, steroid-eluding stent on laryngotracheal complex (LTC) granulation in the murine model. We hypothesize that steroid treated LTCs will have reduced granulation compared to non-treated LTCs using 2 techniques. Method: The established murine model of LTC stenosis was used to compare effects of local mometasone furoate on airway granulation tissue. Using H&E staining, the thickness of lamina propria between control and treatment LTCs were compared. Using real-time PCR, the relative level of IL1 and TGF beta were compared. Results: Using microscopy and H&E staining, the LTCs were found to have decreased amounts of granulation after treatment with mometasone furoate compared to untreated LTCs. Using RT-PCR, the inflammatory marker IL-1 was significantly decreased in LTCs treated with the mometasone furoate stent compared to untreated mice. Conclusion: Localized drug eluding stent appears to decrease granulation and inflammatory markers within laryngotracheal complexes. Further investigation into the therapeutic benefit of local drug-eluding stents in the airway is warranted.
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