Abstract
Murine mammary carcinoma (FM3A TK −/HSV-1 TK +) cells, which are thymidine kinase (TK)-deficient but have been transformed with the herpes simplex virus type 1 (HSV-1) TK gene are inhibited in their growth by ( E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), ( E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) and ( E)-5-(2-bromovinyl)-2'-deoxycytidine (BVDC) at 0.5, 0.5 and 0.8 ng ml , respectively; i.e., a concentration 5000 to 20000-fold lower than that required to inhibit the growth of the corresponding wild-type FM3A/0 cells. Hence, transformation of tumor cells with the HSV-1 TK gene makes them particularly sensitive to the cytostatic action ofBVDU and related compounds.
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