Abstract
Swiss mice were inoculated intraperitoneally with erythrocytes infected with Plasmodium berghei. Analysis of serum electrophoretograms during the infection revealed a temporary increase in gamma globulin and a concomitant albumin decrease in close relation with the peaks of the undulant parasitemia. In plasma no decrease in albumin could be registered. Most probably the fibrinogen concentration decreased during the first phase of the disease to below detectable levels in the electrophoretogram. The addition of hemoglobin to normal serum or to serum of infected mice resulted in a false positive increase in gamma globulin. Based on the very specific immunologic precipitation no increase in gamma globulin in the first phase of the disease was demonstrable.
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