Abstract
Highly immunogenic lymphoma sublines were obtained following treatment with dimethyl-triazeno-imidazole-carboxamide (DTIC) in vivo . The host's immune responses against parental (PL) and DTIC-treated sublines (DTS) were studied in mice presensitized with irradiated PL or DTS and challenged intraperitoneally with viable lymphoma cells. Tumor growth was monitored by evaluation of the uptake of 125 I-Iodo-deoxy-uridine ( 125 IUdR) in the peritoneal cavity of mice and by survival of recipient hosts. The results of the experiments showed that growth inhibition of PL occurred in mice sensitized with irradiated PL or DTS. On the other hand tumor inhibition or enhancement was observed in mice sensitized with irradiated DTS and challenged with viable cells of the DTIC-treated lymphomas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
