Abstract
Endometriosis is a chronic, gynecologic disease afflicting 1-in-10 reproductive-aged women. Response to medical therapy is highly variable as endometriotic lesions do not consistently respond to first-line, progestin-based therapy. We have previously demonstrated in a retrospective study that progesterone receptor (PR) status in lesions can predict response to progestins. Low PR status was associated with a <10% chance of response, suggesting that some women may benefit from alternative hormonal therapy as first-line.
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