Abstract
Throughout oogenesis, Drosophila egg chambers traverse the fine line between survival and death. After surviving the ten early and middle stages of oogenesis, egg chambers drastically change their size and structure to produce fully developed oocytes. The development of an oocyte comes at a cost, the price is the lives of the oocyte’s 15 siblings, the nurse cells. These nurse cells do not die of their own accord. Their death is dependent upon their neighbors—the stretch follicle cells. Stretch follicle cells are nonprofessional phagocytes that spend the final stages of oogenesis surrounding the nurse cells and subsequently forcing the nurse cells to give up everything for the sake of the oocyte. In this review, we provide an overview of cell death in the ovary, with a focus on recent findings concerning this phagocyte-dependent non-autonomous cell death.
Highlights
More than 300 billion cells die in a human body every day [1,2]
Drosophila melanogaster has proven to be a valuable model for studying phagoptosis as several examples of phagocyte-dependent cell death have been reported, with two forms identified in the ovary [27,29,30,31]
As it relies exclusively on nonprofessional phagocytes for clearance and its egg chambers undergo a variety of cell death events, the Drosophila ovary provides a versatile and optimal environment for studying nonprofessional phagocytosis
Summary
More than 300 billion cells die in a human body every day [1,2]. this number may seem daunting, this is a typical day for a healthy human adult. Drosophila melanogaster has proven to be a valuable model for studying phagoptosis as several examples of phagocyte-dependent cell death have been reported, with two forms identified in the ovary [27,29,30,31]. The ovary of Drosophila is an excellent tissue for studying cell death and corpse clearance as several death events take place throughout oogenesis [32,33,34,35,36,37,38]. Drosophila are small animals, there are several accessible tissues for studying cell death and clearance including the brain, fat body, and ovaries [47,48]. An ovariole is composed of several egg chambers at different stages of development
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