Multivariate generalizations of jonckheere's test for ordered alternatives

Abstract

In many dose-response studies, each of several independent groups of animals is treated with a different dose of a substance. Many response variables are then measured on each animal. The distributions of the response variables may be nonnormal, and Jonckheere's (1954) test for ordered alternatives in the one-way layout is sometimes used to test whether the level of a single variable increases with increasing dose. In some applications, however, it is important to consider a set of response variables simultaneously. For instance, an increase in each of certain enzymes in the blood serum may suggest liver damage. To test whether these enzyme levels increase with increasing dose, it may be preferable to consider these enzymes as a group, rather than individually. I propose two multivariate generalizations of Jonckheere's univariate test. Each multivariate test statistic is a function of coordinate-wise Jonckheere statistics—one a sum, the other a quadratic form. The sum statistic can be used to test the alt...