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Abstract
The simplicity of object shape and composition modification make additive manufacturing a great option for customized dosage form production. To achieve this goal, the correlation between structural and functional attributes of the printed objects needs to be analyzed. So far, it has not been deeply investigated in 3D printing-related papers. The aim of our study was to modify the functionalities of printed tablets containing liquid crystal-forming drug itraconazole by introducing polyvinylpyrrolidone-based polymers into the filament-forming matrices composed predominantly of poly(vinyl alcohol). The effect of the molecular reorganization of the drug and improved tablets’ disintegration was analyzed in terms of itraconazole dissolution. Micro-computed tomography was applied to analyze how the design of a printed object (in this case, a degree of an infill) affects its reproducibility during printing. It was also used to analyze the structure of the printed dosage forms. The results indicated that the improved disintegration obtained due to the use of Kollidon®CL-M was more beneficial for the dissolution of itraconazole than the molecular rearrangement and liquid crystal phase transitions. The lower infill density favored faster dissolution of the drug from printed tablets. However, it negatively affected the reproducibility of the 3D printed object.
Highlights
Additive manufacturing has huge potential to revolutionize the methods of drug delivery system formation
We describe for the first time the liquid crystal phase transitions of itraconazole in 3D printed tablets
The diameter of the filaments was kept at a constant level; in the case of the PVA_K/CL
Summary
Additive manufacturing has huge potential to revolutionize the methods of drug delivery system formation. It was proven for mass-scale drug production by Aprecia Pharmaceuticals, which registered the first 3D printed drug, Spritam® , in 2015. The issue of the correlation between the internal structure of printed tablets and their properties, the dissolution characteristics, has been explored by several research teams, there is still deficiency in studies on the actual microstructure and quality of printed objects and the mechanisms driving the release of the drug from printed dosage forms [6,7,8,9]
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