Abstract
Mental problems caused by various kinds of stress induce neurotoxic damage through biological mechanisms like oxidation or metabolic unbalancing. We evaluated the dietary supplementation of antioxidant and nutrition, ubiquinol with milk in normal isolated adult common marmoset (Callithrix jacchus) as a preliminary preclinical study. The primates were fed with milk with or without ubiquinol every day for three months and after a two-month-interval, the treatment conditions were alternated. Psycho-physiological state was evaluated by video-recording of social behavior, body temperature detection by a simple IR thermal camera and a blood glucose chip-sensor. Furthermore, social behavior data were information-processed by technology to integrate multiple factors, ‘Behavior output analysis for quantification of emotional state translation’ abbreviated as BOUQUET, which visualized a statistical partial space where the status of high ubiquinol and low ubiquinone in plasma strongly correlated with high frequency of social approaching behavior and lower body temperatures in a social meeting context. This analysis also suggested that high frequency of face direction to a peer correlated with the high ubiquinol-low ubiquinone and high variation of body temperature. Blood glucose seemed weakly relevant to alert behavior in this multiple correlation. These results imply that unbiquinol supplementation promotes social motivation. Finally, the result that the BOUQUET and the sensor systems revealed the implicit psycho-physiological information suggests its applicability in various toxico-psychopathological studies as quantitative manner.
Highlights
An etiological study of psychiatric disorders has suggested that the stress from complex socio-economical as well as toxicochemical environment triggers inflammation and oxidative reaction to yield depression through neurotoxic impairment [1]
The method is a kind of information processing based on principal component analysis of behavior parameters captured by video-recordings and makes it possible to extract socio-emotional features as a higher order correlation in a novel non-human primate model, common marmoset (Callithrix jacchus) [2,3]
We challenged to search what was affected by this nutritive support in social behavior with psycho-physiological factors, blood glucose [15,16] and body temperatures [17,18] by a novel system of BOUQUET to objectively diagnose psychological modulation of the multiple kinds of parameters
Summary
An etiological study of psychiatric disorders has suggested that the stress from complex socio-economical as well as toxicochemical environment triggers inflammation and oxidative reaction to yield depression through neurotoxic impairment [1]. We need to develop early detection method of mental modulation which could develop severe mental disorder if no appropriate action was taken to prevent its progress. It is, still hard problem to quantitatively measure any mental modulation. The method is a kind of information processing based on principal component analysis of behavior parameters captured by video-recordings and makes it possible to extract socio-emotional features as a higher order correlation in a novel non-human primate model, common marmoset (Callithrix jacchus) [2,3]. The current study of primate psychological model focused on their social response because any psychiatric diseases or mental problems certainly concern social emotion, cognition and other psychology [4,5]. We challenged to search what was affected by this nutritive support in social behavior with psycho-physiological factors, blood glucose [15,16] and body temperatures [17,18] by a novel system of BOUQUET to objectively diagnose psychological modulation of the multiple kinds of parameters
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