Abstract

Objective To investigate the effect factors of Vitamin K1 maintenance dose in patients with anticoagulant rodenticide poisoning. Methods This retrospective study was analyzed 36 cases in our hospital from January 2013 to October 2014. The correlation between Vitamin K1 and types of anticoagulant rodenticide and toxic dose, prothrombin time activity (PTA), prothrombin time (PT), activated partial thromboplastin time (APTT), prehospital duration (from poisoning to hospitalization), and length of hospital stay (duration of Vitamin K1 treatment) were collected and analyzed by Spearman rank correlation analysis and multivariate regression analysis. Results The dose of Vitamin K1 was positively correlated with brodifacoum (r=0.356, P 0.05). The multivariate regression analysis also showed that prehospital duration [95% confidence interval: (-0.536, -0.103), P=0.002] and length of hospital stay [95% confidence interval: (-1.955, -0.248), P=0.013] had significant effect on the maintenance dose of vitamin K1 in the patients with coagulation function stable. Conclusion After stabilizing the coagulation function, the demanded maintenance dose of vitamin K1 can be gradually decreased with time prolonged, and have no relationship with type of anticoagulant rodenticide and toxic dose. Key words: Anticoagulant rodenticide; Poisoning; Vitamin K1; Multivariate analysis

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