Multivariate analysis of prognostic factors in 112 patients with small cell lung cancer

Abstract

Objective To analyze the prognostic factors in patients with small cell lung cancer(SCLC). Methods Clinical data of 112 patients with small cell lung cancer diagnosed by histopathology or Cytology were col-lected. The relationship between gender, age, stage, the level of Hemoglobin (Hb) and lactate dehydrogenase (LDH), the efficacy of first -line chemotherapy, radiotherapy and operation with the survival time was analyzed. Ka-plan-Meler, COX multivariate proportional hazards model and Log-rank test were used to analyze the prognostic fac-tors. Results 1, 2, and3 year survival rate was71.4%, 38.4% and 14.3% respectively,80.0%,47.1% and 17.1% in limited disease (LD) patients,57.1%,23.8% and 9.5% in extensive disease (ED) patients. Median survival time (MST) of all the patients was 22 months, 24 months in LD, and 16 months in ED. Univariate analysis indicated that stage, Hb, LDH, the efficacy of first-line chemotherapy, radiotherapy and operation significantly in-fluenced survival in SCLC. Multivariate analysis suggested that stage, the efficacy of first-line chemotherapy, radio-therapy and operation were the independent prognositic factors of survival (relative risk degree=0.687, 0.635, 0.412, 0.203). Conclusion Stage, efficacy of first-line chemotherapy, radiotherapy and operation are the impor-tant prognostic factors for patients with SCLC. Key words: Small cell lung cancer; Prognosis; Multivariate analysis