Multivariate analysis of prognosis of patients with upper urinary tract transitional cell carcinoma

Abstract

Objective:To retrospectively analyze the clinical data of 71 patients with upper urinary tract transitional cell carcinoma (UUT-TCC), so as to assess the prognosis of patients and search for factors influencing the prognosis of patients. Methods: Totally 71 UUT-TCC patients treated surgically from Feb. 2004 to Jan. 2007 were included in this study. All patients underwent radical nephroureterectomy via retroperitoneoscopic approach or open approach. The patients were followed up once a month after operation. Traditional prognostic factors including age, sex, tumor stage, grade, location, type of surgical treatment and some pathological biomarkers, such as p53, Ki-67, nm23, and C-erB-2, were collected and analyzed with respect to disease-specific survival by Kaplan-Meier method. Predictive factors influencing the disease-specific survival were also analyzed by Cox proportional hazards model. Results: The 1-, 2-or 3-year disease-specific survival rates were 95.8 %, 89.3% and 83.5%, respectively. Only tumor stage was found to be a factor for prognosis by multivariate analysis (P0.001). Conclusion: Tumor stage is an independent predictor of disease-specific survival. Retroperitoneoscopic radical nephroureterectomy achieves similar outcomes to the traditional open surgery on oncology control, with the long-term outcome remains to be further studied.