Abstract
Multivariate analysis techniques could be used to identify possible intercorrelations in intoxications cases. The statistical analyses used were a multiple logistic regression, multiple correspondence analysis, principal component and hierarchical cluster analysis. Of the 320 samples analysed, 192 samples were positive for some of the investigated toxic agents, of which 100 were positive for ethanol and 131 were positive for other substances. It was possible to group the patients into 3 clusters, which appears 66.5% of this information in the three first factorial axes. On the first axis, the male patients were separated from the female patients. Patients exposed to drugs, between 30 and 39 years old were grouped in the same cluster. On the second factorial axis, patients who were intoxicated with ethanol and who became intoxicated with diazepam were grouped. This work contributed to the mapping of intoxication cases at the Poison Control Centre of the São Paulo city, Brazil (CCI-SP) and serves as an initial study for the creation of a database that could be updated constantly and thus could provide a toxicovigilance system for educational policies.
Highlights
Multivariate analysis techniques could be used to identify possible intercorrelations in intoxications cases
Multivariate analysis techniques have been applied in several sectors and adopted in scientific research to verify whether studied variables are correlated
The analysis of multiple correspondence analysis (MCA) and hierarchical cluster analysis (HCA), are justified by their ability to group patients profiles by the proximity that individuals are in the mathematical space in the graph generated by the MCA and to be grouped due to the similarity of the data of the variables of the individuals[15]
Summary
Multivariate analysis techniques could be used to identify possible intercorrelations in intoxications cases. With the application of multivariate analysis in cases of intoxication, it is possible to characterize the events and provide sufficient information to support educational actions related to the prevention of intoxication, as well as to provide advice on the treatments of intoxication and to increase capacity for diagnosing suicidal behaviour in emergency services. The purpose of this work was to identify and quantify exogenous agents in biological samples from the Poison Control Centre of the São Paulo city (CCI-SP), correlating the data obtained from these analyses with www.nature.com/scientificreports the clinical outcome of the patients, through multivariate analysis and aiming to contribute to the improvement of Brazilian health care services
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