Multivalency associated properties of polysulfated nanomaterials in biomedical applications

Abstract

1\. Introduction 1.1 Multivalency and binding inhibition 1.1.1 Definition and quantification of multivalency 1.1.2 Multivalency in competitive binding inhibition 1.2 Polysulfates and their biological interactions 1.2.1 Anti- inflammatory properties of polysulfates 1.2.3 Polyanions and their application as viral entry inhibitors 1.3 Inorganic nanomaterials for biomedical applications 1.3.1 Stability of colloidal dispersions – The DLVO theory 1.3.2 Biocompatibility of colloids 1.3.3 Synthesis of inorganic nanoparticles 1.3.4 Stabilizing ligands and functionalization of inorganic nanoparticles 1.3.5 Material-derived properties and applications of inorganic nanomaterials 1.3.6 Dimension-derived properties and applications of inorganic nanomaterials 2\. Motivation and Objective 3\. Publications and Manuscripts 3.1 Polyglycerolsulfate functionalized gold nanorods as optoacoustic signal nanoamplifiers for in vivo bioimaging of rheumatoid arthritis 3.2 Virus inhibition induced by polyvalent nanoparticles of different sizes 3.3 Size Dependence of Steric Shielding and Multivalency Effects for Globular Binding Inhibitors 4\. Summary and Conclusion 5\. Outlook 6\. Abstract and Kurzzusammenfassung 6.1 Abstract 6.2 Kurzzusammenfassung 7\. References