Abstract
In this study, we propose a novel, multiturn histology coil for microscopic magnetic resonance (MR) imaging of histological tissue slices with substantially higher signal-to-noise-ratio (SNR) outcomes compared with previously developed coils. We performed electromagnetic simulations of the proposed coils and acquired MR images from a gelatin phantom and a rat brain slice with the implemented coils. The performances of the coils were evaluated by comparing the measured and simulated radio-frequency transmission (B<sub>1</sub><sup>+</sup>) fields in a flip-angle map form, and with low flip-angle gradient echo images to calculate the SNR increase as a function of the number of turns (<i>n</i>) of the coils. This study was performed on a 3 T MR imaging system. The proposed coil with <i>n</i> = 7 achieved SNR greater than 3.5 times that of a single-turn coil while preserving the highly uniform B<sub>1</sub><sup>+</sup> field across the imaging region. The proposed method provides new possibilities for high-resolution MR imaging of microscopic tissue samples for biomedical applications.
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