Abstract
Evasion of the host’s immune system is a required step for the establishment of viral infection. In this article, we discuss the recent findings of Heidmann and colleagues demonstrating that some retroviruses possess an immune suppressive (IS) domain “encrypted” within their envelope glycoprotein that is required to establish a successful infection in immunocompetent hosts [1].
Highlights
Evasion of the host’s immune system is a required step for the establishment of viral infection
The immune-modulator function of some retroviruses was first noted in the early sixties, when it was described that both humoral and cell mediated immunity was impaired when mice were infected with Gross passage A leukemia virus [10]
The authors used Friend murine leukemia virus (F-MLV) and a viral mutant with two key residues within the immune suppressive (IS) domain replaced by the corresponding residues from SYNCYTIN-1
Summary
Evasion of the host’s immune system is a required step for the establishment of viral infection. The immune-modulator function of some retroviruses was first noted in the early sixties, when it was described that both humoral and cell mediated immunity was impaired when mice were infected with Gross passage A leukemia virus [10].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
