Multisystemic inflammatory syndrome in children (MIS-C) temporally associated with SARS-CoV-2

Abstract

OBJECTIVE: To analyze the Pediatric Multisystem Inflammatory Syndrome (MIS-C), reported during the COVID-19 pandemic, in the context of all its clinical exuberance, affecting several organ systems of children and adolescents previously positive for the virus of SARS-CoV-2 and so, collaborate with the stratification of risk groups at COVID-19 and contribute with information to the scientific research community. METHOD: A literature review was carried out in the PubMed and MEDLINE databases, using the keywords of the terminologies registered in the Health Sciences Descriptors created by the Virtual Health Library and developed from the Medical Subject Headings of the US National Library of Medicine (MeSH) of 19 articles from the years 2020 and 2021 about the COVID-19 and Multisystem Inflammatory Syndrome in children. RESULTS: The epidemiological importance of the MIS-C diagnosis was identified, as it became a pediatric emergency during the SARS-CoV-2 pandemic. In addition, there was great difficulty in the differential diagnosis with other pediatric pathologies, such as Kawasaki Disease (KD). However, it has already been possible to observe clinical and laboratory differences between them. CONCLUSION: It is essential to carry out further research to fully elucidate the pathophysiological mechanisms of the disease, however, its clinical importance is already evident, since its evolution can be severe. Therefore, it is imperative that children and adolescents between 3 and 19 years old practice the necessary prevention measures to prevent contamination, as the children who manifested MIS-C were those positive for the SARS-CoV-2 virus.