Abstract
Background: Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory condition associated with COVID-19 in children, with features that are similar to Kawasaki disease and toxic shock syndrome. Several reports are emerging from all over the world on this condition that is associated with increased fatality rate. Case Report: In this article, we present one of the first reports of a newborn diagnosed with MIS-C attributed to COVID-19. In addition, we discuss the diagnostic criteria and the possible pathophysiology. Conclusion: Although COVID-19 does not frequently affect newborns, when it does, it may lead to devastating complications, such as MIS-C. As a result, providers should be on the lookout for any symptoms that can indicate a complicated infection. Further studies are still needed to develop a better understanding of the pathophysiology of this disease and establish appropriate therapeutic guidelines.
Highlights
Since December 2019, the time of emergence of the first case of coronavirus (SARS-CoV-2) in Wuhan, China, the virus has been considered as a wild variant in children
COVID-19 does not frequently affect newborns, when it does, it may lead to devastating complications, such as Multisystem inflammatory syndrome in children (MIS-C)
A small subset of pediatric patients required hospitalization. This was documented in the United States, where approximately 2% of COVID-19 cases were less than 18 years of age [2, 3]
Summary
COVID-19 infrequently affects newborns, if a newborn is diagnosed with it, it can lead to devastating complications, such as MIS-C. Providers should be on the lookout for it if some of these signs and symptoms are present: Gastrointestinal symptoms such as diarrhea or vomiting, fever, rash, respiratory symptoms, abnormal blood cell count, elevated inflammatory markers, elevated cardiac markers, acute kidney injury, acute respiratory failure and shock. Further studies are still needed to better understand the pathophysiology of this illness and suggest appropriate therapeutic interventions
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