Multisystem inflammatory syndrome associated to COVID-19 in pediatric population.

Abstract

The new SARS-CoV-2 coronavirus appears to be less aggressive in the pediatric population in comparison to the adult population. Yet, most recently, as the number of diagnosed pediatric patients with COVID-19 has increased, clinicians have observed the development of a multisystemic inflammatory response syndrome that is potentially associated with COVID-19 in the pediatric population. Our objective was to retrieve and synthesize the reports that have described the multisystemic inflammatory response syndrome potentially associated with COVID-19 in the pediatric population. We conducted a narrative review of scientific literature reported in PubMed from January 1st to June 30th, 2020, with the terms multisystem inflammatory syndrome, Kawasaki, children, COVID-19. This new syndrome has been associated with greater difficulty in treating children with COVID-19 and some deaths have been observed as a result. On the other hand, innate pediatric immunity, primarily driven by IgM, and the rapid immune response to generate germ-center dependent and non-dependent memory B cells as it has been hypothesized for other authors could largely explain the behavior and incidence of the new SARS-CoV-2 infection in the pediatric population.