Multisensory integration, body representation and hyperactivity of the immune system.

Abstract

Multisensory stimuli are integrated over a delimited window of temporal asynchronies. This window is highly variable across individuals, but the origins of this variability are still not clear. We hypothesized that immune system functioning could partially account for this variability. In two experiments, we investigated the relationship between key aspects of multisensory integration in allergic participants and healthy controls. First, we tested the temporal constraint of multisensory integration, as measured by the temporal binding window. Second, we tested multisensory body representation, as indexed by the Rubber Hand Illusion (RHI). Results showed that allergic participants have a narrower temporal binding window and are less susceptible to the RHI than healthy controls. Overall, we provide evidence linking multisensory integration processes and the activity of the immune system. The present findings are discussed within the context of the effect of immune molecules on the brain mechanisms enabling multisensory integration and multisensory body representation.