Abstract
Lab-on-a-chip systems are very promising approach for a decentralized continuous pathogen monitoring. The overall presented system consisting of a microtiter plate sized consumable and the respective instrument allows for the detection of airborne biological pathogen. The target pathogens to be detected are Yersinia pestis, Francisella tularensis, Burkholderia mallei, Burkholderia pseudomallei, Brucella melitensis, Brucella abortis, Coxiella burnetti, and Bacillus anthracis. Important to stress that the technical platform can be easily expanded to further pathogens. In this paper the development of a fully integrated system for the 8-plex detection of bacterial pathogens will be presented. Two exceptional features are combined in this device: The overall system allows for the permanent sampling and analysis of airborne biological pathogens and combines the detection of the respective bacteria on molecular and immunological level. The overall system consisting of chip and instrument and the biological procedures embedded on chip will be presented.
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