Abstract
<p style='text-indent:20px;'>This paper focuses on the multiscale modeling of the COVID-19 pandemic and presents further developments of the model [<xref ref-type="bibr" rid="b7">7</xref>] with the aim of showing how relaxations of the confinement rules can generate sequential waves. Subsequently, the dynamics of mutations into new variants can be modeled. Simulations are developed also to support the decision making of crisis managers.</p>
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